Signal Transduction Reagents and Kits
Abcam Ascorbic Acid Assay Kit (Biological Samples)
Ascorbic Acid Assay Kit (Biological Samples)
The product is subject to the following: Abcam Restricted Use Statement
Echelon Biosciences Research Labs PI(5)P DIC8 AMMONIUM SALT 500 ug
Phosphatidylinositol 5-phosphate diC8 (PI(5)P diC8) is a synthetic, purified dioctanoyl PI(5)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4,5)P2 by Type II PIP kinases. This item is non returnable
Enzo Life Sciences Z-prolyl-prolinal (25mg). CAS: 86925-97-5
A potent and selective inhibitor of prolyl endopeptidase (PEP/PREP/POP, EC 3.4.21.26). Ki=0.35 nM for mouse brain enzyme. Inhibits the cleavage of arginine-vasopressin, gonadotropin-releasing hormone, and other peptides. Alternative name: Z-PP-CHO. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Abcam Angiotensin Converting Enzyme 1 (ACE1) Inhibitor Screening Kit (Colorimetric)
Angiotensin Converting Enzyme 1 (ACE1) Inhibitor Screening Kit (Colorimetric)
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences MMP-Inhibitor profiling kit, fluorometric (1x96wells)
A QUANTIZYME Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a sensitive fluorogenic substrate . Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Applications: Fluorescent detection, HTS Activity assay.
Medchemexpress LLC Veratridine | 71-62-5 | 10 MG
Veratridine is a plant neurotoxin and a voltage-gated sodium channel (VGSCs) agonist. It inhibits the peak current of Nav1.7 with an IC50 of 18.39 μM. It regulates sodium ion channels by activating them, preventing channel inactivation, and increasing sodium ion flow. This product is for research use only.
- Plant neurotoxin
- Voltage-gated sodium channels (VGSCs) agonist
- Inhibits peak current of Nav1.7
- Regulates sodium ion channels by activation
- Prevents channel inactivation
- Increases sodium ion flow
Medchemexpress LLC Tulobuterol (C-78 free base) | 41570-61-0 | 99.7% | 50 MG
Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. It is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.
- Decreases RV14 RNA levels at 1 day and 3 days after infection in human tracheal epithelial cells.
- Significantly lowers sICAM-1 concentrations in cell supernatants.
- Reduces the number and fluorescence intensity of acidic endosomes.
- Decreases RV14 infection-induced secretion of IL-1β, IL-6, and IL-8.
- Produces a small but significant reduction in p50, p65, and c-Rel of NF-κB induced by RV14 infection.
- Maintains diaphragm muscle contractility for over 24 hours in a mouse model of sepsis.
Enzo Life Sciences Lysophosphatidic acid, (5mg), CAS Number: 325465-93-8
LPA receptor ligand. Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons. Alternative Name: 1-Oleoyl-lysophosphatidic acid . sodium salt. Formula: C21H40O7P . Na. MW: 458.5. CAS Number: 325465-93-8. Purity: ≥98% (TLC). Appearance: Waxy solid. Solubility: Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Use/Stability: Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month. Long Term Storage: -20°C
Enzo Life Sciences Salubrinal (1mg). CAS: 405060-95-9
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (BML-CC104)). Purity: ≥98% (HPLC(UV)). Solubility: Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). Long Term Storage: -20°C.
Apexbio Technology LLC highly selective, potent and cell-permeable p38 MAPK inhibitor 152121-30-7. MFCD00941964
highly selective, potent and cell-permeable p38 MAPK inhibitor 152121-30-7. MFCD00941964
Abcam Glucose-6-Phosphate Assay Kit (Colorimetric)
Glucose-6-Phosphate Assay Kit (Colorimetric)
The product is subject to the following: Abcam Restricted Use Statement
Carnabio Usa Inc CK1G1(CSNK1G1)/5UG/FULL-LENGTH
CK11(CSNK1G1), Full-length, Wild type, Amino Acid 1-422, NP_071331.2, Expressed in Insect (sf21); 5microg
Medchemexpress LLC Allocryptopine | 485-91-6 | 99.7% | 369.41 g/mol | C21H23NO5 | 10 MG
Allocryptopine is a dibenzazecine alkaloid (C21H23NO5, MW 369.41 g/mol) used as a potassium-channel inhibitor in cardiovascular and ion-channel research. Supplied in small research pack sizes with high reported purity, the compound is intended for in vitro and other laboratory applications as a research reagent.
- Chemical formula: C21H23NO5
- Molecular weight: 369.41 g/mol
- CAS number: 485-91-6
- Purity: 99.7%
- Target: Potassium channel inhibitor (hERG-related activity)
- Intended use: Research use only
- Typical pack size: 10 MG
Enzo Life Sciences SB203580, (1mg), CAS Number: 152121-47-6
Protein kinase inhibitor. Cell permeable, specific inhibitor of p38 (SAPK2a). Inhibits p38 MAPK stimulation of MAPKAPK2 (IC.The concentrations of SB203580 required to block Akt phosphorylation (IC50= 3-5µM) are only approximately 10-fold higher than those required to inhibit p38 MAP kinase (IC50=0.3-0.5µM). These data define a new activity for this drug and suggest that extreme caution should be used when interpreting data when SB203580 has been used at concentrations above 1-2µM. Non-specific effects include inhibition of COX-1 and -2. Enhances clonal growth of skin epithelial progenitor cells and stimulates neural stem cell proliferation. Alternative Name: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole. Formula: C21H16N3FOS. MW: 377.4. CAS Number: 152121-47-6. Purity: ≥97% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO (50mg/ml). Long Term Storage: -20°C